|Description:||Rabbit polyclonal antibody to Axin1.|
|Dilutions:||WB: 1:500 - 1:1000, IHC: 1:50 - 1:100.|
|Immunogen:||A synthetic peptide of human AXIN1.|
|Formulation:||Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.|
|Storage:||Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.|
|Function:||Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7. Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development.|
|Tissue Specificity:||Ubiquitously expressed.|
|Involvement in Disease:||Hepatocellular carcinoma: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.
Caudal duplication anomaly: A condition characterized by the occurrence of duplications of different organs in the caudal region.
|Post-Translational Modification:||Phosphorylation and dephosphorylation of AXIN1 regulates assembly and function of the beta-catenin complex. Phosphorylated by CK1 and GSK3B. Dephosphorylated by PPP1CA and PPP2CA. Phosphorylation by CK1 enhances binding of GSK3B to AXIN1.|
|Cellular Location:||Cytoplasm. Nucleus. Membrane. Cell membrane.
MACF1 is required for its translocation to cell membrane (By similarity). On UV irradiation, translocates to the nucleus and colocalizes with DAAX (PubMed:17210684).
Axin 1 Antibody
Axis inhibition protein 1 Antibody
Axis Inhibitor 1 Antibody
Fused, mouse, homolog of Antibody
Protein Fused Antibody
Protein phosphatase 1 regulatory subunit 49 Antibody
|Information:||Target information shown above is from the UniProt Consortium.|