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Anti-Axl Antibody

Rabbit polyclonal antibody to Axl from ABclonal (A0532).
Name: Anti-Axl Antibody
Description: Rabbit polyclonal antibody to Axl.
Applications: WB, IHC, FC
Dilutions: WB: 1:500 - 1:1000, IHC: 1:50 - 1:100, FC: 1:20 - 1:50.
Reactivity: Human
Immunogen: A synthetic peptide of human AXL.
Protein Length: 894
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
Tissue Specificity: Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.
Sequence Similarities: Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Post-Translational Modification: Monoubiquitinated upon GAS6-binding. A very small proportion of the receptor could be subjected to polyubiquitination in a very transient fashion.
Cellular Location: Cell membrane.
UniProt: P30530
Gene ID: 558
Synonyms: Adhesion related kinase Antibody
AI323647 Antibody
Ark Antibody
AXL oncogene Antibody
AXL receptor tyrosine kinase Antibody
AXL transforming gene Antibody
AXL transforming sequence/gene Antibody
EC 2.7.10.1 Antibody
JTK11 Antibody
Oncogene AXL Antibody
Tyro7 Antibody
Tyrosine protein kinase receptor UFO Antibody
Tyrosine-protein kinase receptor UFO Antibody
UFO Antibody
UFO_HUMAN Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of extracts of HepG2 cell line, using AXL antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to Axl (Phospho-Tyr691)
Application: WB, IHC, ELISA
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human Axl around the phosphorylation site of Y691.

£180 – £234

Description: Rabbit Polycolonal antibody to AXL (Phospho-Tyr702)
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: A synthesized peptide derived from human AXL (Phospho-Tyr702)

£180 – £234

Description: Rabbit polyclonal antibody to AXL (phospho-Y703)
Application: WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic phosphopeptide derived from human AXL around the phosphorylation site of Tyrosine 703.

£175 – £302

Description: Rabbit polyclonal antibody to Axl
Application: ELISA, IP, WB
Host: Rabbit
Reactivity: Human, Monkey, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 840-880 on mouse AXL protein. The peptide was post translationally modified to acheive proper orientation and antigenicity.

£372

Please Note: Anti-Axl Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0532
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe