Recombinant Anti-Bcl6 Antibody [BCL6/8983R] (A314492)

$765

Recombinant rabbit monoclonal [BCL6/8983R] antibody to Bcl6 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Bcl6 Antibody [BCL6/8983R]
Description
Recombinant rabbit monoclonal [BCL6/8983R] antibody to Bcl6.
Specificity
Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative. (2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas (DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes. (3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large ( LH ) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.
Applications
IHC-P
Positive Control
Raji or Ramos cells. Human tonsil or Hodgkin s lymphoma.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment (aa1-400) of human BCL6 protein. The exact sequence is proprietary.
Host
Rabbit
Clonality
Monoclonal
Clone ID
BCL6/8983R
Isotype
IgG
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
95 kDa
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
B cell CLL/lymphoma 6, B cell lymphoma 6 protein, B-cell lymphoma 5 protein, B-cell lymphoma 6 protein, BCL 5, Bcl 6, BCL-5, BCL-6, BCL5, BCL6A, BCL6_HUMAN, cys his2 zinc finger transcription factor, LAZ 3, LAZ 3 protein, LAZ3, Lymphoma associated zinc finger gene on chromosome 3, Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3), Protein LAZ-3, ZBTB 27, ZBTB27, Zinc finger and BTB domain containing protein 27, Zinc finger and BTB domain-containing protein 27, Zinc finger and BTB domain-containing protein 27 (ZBTB27), Zinc finger protein 51, Zinc Finger Protein 51 (ZNF51), zinc finger transcription factor BCL6S, ZNF 51, ZNF51
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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