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Anti-BORIS Antibody

 
Rat monoclonal (KT72) antibody to BORIS from Absea Biotechnology (061502E05).
Overview
Name: Anti-BORIS Antibody
Description: Rat monoclonal (KT72) antibody to BORIS.
Applications: WB, IF
Reactivity: Mouse
Immunogen: Recombinant mouse BORIS.
Amino Acid Start: 177
Amino Acid End: 420
Host: Rat
Clonality: Monoclonal
Clone: KT72
Isotype: IgG2a
Conjugate: Unconjugated
Purification: Antibody is purified from culture supernatant using a protein G column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target
Function: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
Tissue Specificity: Testis-specific.
Sequence Similarities: Belongs to the CTCF zinc-finger protein family.
Cellular Location: Cytoplasm. Nucleus.
UniProt: A2APF3
Gene ID: 664799
Synonyms: BORIS like protein Antibody
Brother of the regulator of imprinted sites Antibody
Cancer/testis antigen 27 Antibody
CCCTC binding factor (zinc finger protein) like Antibody
CCCTC-binding factor Antibody
CT27 Antibody
CTCF paralog Antibody
CTCF T Antibody
CTCF-like protein Antibody
Ctcfl Antibody
CTCFL_HUMAN Antibody
dJ579F20.2 Antibody
HMG 1L1 Antibody
HMGB1L1 Antibody
MGC163358 Antibody
MGC169105 Antibody
MGC169106 Antibody
Putative high mobility group protein 1 like 1 Antibody
Putative high mobility group protein B1 like 1 Antibody
Transcriptional repressor CTCFL Antibody
Zinc finger protein CTCF-T Antibody
Information: Target information shown above is from the UniProt Consortium.


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Please Note: Anti-BORIS Antibody is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | 061502E05
Size Price Quantity
100µg £186
200µg £273
1mg £730

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