Anti-Caspase-3 Antibody (A283703)

Anti-Caspase-3 Antibody

Rabbit polyclonal antibody to Caspase-3.

This antibody recognises caspase-3 also known as cysteine protease CPP32. Caspase-3, as the name implies, is a member of the cysteine-aspartic acid protease (caspase) protein family.Caspase-3 is an effector caspase that is activated by both the intrinsic and extrinsic apoptosis pathways. Caspase-3 is cleaved from an inactive 32 kDa zymogen/pro-enzyme into p17 and p12 subunits by the activated initiator caspases 9 and 8 in apoptotic cells. These subunits dimerize to form the active caspase 3 protein that cleaves and activates caspase-6 and 2. Through the activation/cleavage of downstream caspases, caspase-3 plays an important role in mediating apoptosis signaling.

WB, IHC-P

IHC-P: 1:50 - 1:200, WB: 1:500 - 1:2,000

Human, Rat, Mouse

Recombinant human caspase-3.

Rabbit

Polyclonal

IgG

Unconjugated

Liquid

Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti caspase-3 antibody recognizes caspase-3 also known as cysteine protease CPP32. Caspase-3, as the name implies, is a member of the cysteine-aspartic acid protease (caspase) protein family.Caspase-3 is an effector caspase that is activated by both the intrinsic and extrinsic apoptosis pathways. Caspase-3 is cleaved from an inactive 32 kDa zymogen/pro-enzyme into p17 and p12 subunits by the activated initiator caspases 9 and 8 in apoptotic cells. These subunits dimerize to form the active caspase 3 protein that cleaves and activates caspase-6 and 2. Through the activation/cleavage of downstream caspases, caspase-3 plays an important role in mediating apoptosis signaling.

A830040C14Rik, Apopain, CASP-3, CASP3, Casp3a, CASP3_HUMAN, Caspase 3, Caspase 3, apoptosis-related cysteine peptidase, Caspase 3, apoptosis-related cysteine protease, Caspase 3, apoptosis-related cysteine protease a, Caspase-3 subunit p12, CC3, CPP-32, CPP32, CPP32B, Cysteine protease CPP32, EC 3.4.22.56, LICE, mldy, OTTHUMP00000165052, OTTHUMP00000165053, OTTHUMP00000165054, PARP cleavage protease, Procaspase3, Protein Yama, SCA 1, SCA-1, SREBP cleavage activity 1, Yama