Anti-AHSG Antibody [AHSG/3748] (A277583)

Anti-AHSG Antibody [AHSG/3748]

Mouse monoclonal [AHSG/3748] antibody to AHSG.

Fetuin (also designated α2-z-globulin or α2-HS-glycoprotein) is a secreted plasma protein that is expressed in hepatocytes, monocyte/macrophages and in bone and is downregulated during injury and inflammation. Fetuin preferentially binds to and carries calcium and barium ions in the blood, where it is thought to mediate serum calcium homeostasis and mineralization, and to potentially participate in the transport of bioactive molecules. Additionally, fetuin has been shown to function as an acute phase anti-inflammatory mediator that is critical to regulating the innate immune response following tissue injury. During inflammation, circulating fetuin levels substantially decrease as fetuin becomes associated with the membranes of macrophages. This membrane associated form of fetuin acts as an opsonic participant by potentiating the entry of cationic small molecules into the activated macro-phage, which in turn facilitates macrophage-deactivating mechanisms. Biologically active fetuin is derived from a precursor protein that is cleaved at the aminoterminus to generate two chains held together by a single disulfide bond.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment corresponding to human AHSG protein. The exact sequence is proprietary.

Mouse

Monoclonal

AHSG/3748

IgG1

Protein A/G chromatography.

200 µg/ml

59 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-AHSG Antibody [AHSG/3748] - BSA and Azide free (A278171).

Alpha-2-HS-glycoprotein, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, FETUA, Fetuin-A