Anti-alpha 1 Antichymotrypsin Antibody [AACT/1451 + AACT/1452] (A277554)

Anti-alpha 1 Antichymotrypsin Antibody [AACT/1451 + AACT/1452]

Mouse monoclonal [AACT/1451 + AACT/1452] antibody to alpha 1 Antichymotrypsin.

It recognizes a protein of 65-76kDa, which is identified antichymotrypsin (AACT). AACT is a plasma protease inhibitor synthesized in the liver as a single glycopeptide chain. In human, the normal serum level of AACT is about one-tenth that of α 1-antitrypsin (AAT), with which it shares nucleic acid and protein sequence homology. Both are major acute phase reactants; their concentrations in plasma increase in response to trauma, surgery and infection. Elevated levels of AACT are widely, but not universally, reported in the cerebrospinal fluid and plasma of AD patients. Prostate-specific antigen (PSA) and its SDS-stable complex with AACT are in widespread use as markers for the diagnosis of prostate cancer. AACT deficiency may also be a possible cause of chronic liver disease. AACTantibody reacts with histiocytes and histiocytic neoplasms. It is widely used to identify histiocytes and tumors derived from them. Acinar tumors of the pancreas and salivary gland may also exhibit AACT positivity.

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 49-187, of human alpha 1 Antichymotrypsin. The exact sequence is proprietary.

Mouse

Oligoclonal

AACT/1451 + AACT/1452

IgG1 + IgG1

Protein A/G chromatography.

200 µg/ml

65-76 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

AACT, ACT, Alpha-1-antichymotrypsin, Cell growth-inhibiting gene 24/25 protein, Serpin A3, SERPINA3