Recombinant Anti-beta Catenin Antibody [CTNNB1/8280R] - BSA and Azide free (A315891)

Anti-beta Catenin Antibody [CTNNB1/8280R] - BSA and Azide free

Recombinant rabbit monoclonal [CTNNB1/8280R] antibody to beta Catenin.

Beta-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. In normal tissues, beta-catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immuno-staining of beta-catenin and E-cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.

Human breast carcinoma.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human β-catenin protein. The exact sequence is proprietary.

Rabbit

Monoclonal

CTNNB1/8280R

kappa

Protein A chromatography.

1 mg/ml

92 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Beta-catenin, Catenin beta-1, CTNNB, CTNNB1