Anti-BMP7 Antibody (A283983)

Anti-BMP7 Antibody

Rabbit polyclonal antibody to BMP7.

This antibody recognises the disulphide-linked homodimeric cysteine knot protein known as human Bone Morphogenetic Protein 7 (BMP-7) or Osteogenic protein 1 (OP-1). BMP-7 is a member of the transforming growth factor beta (TGF-B) superfamily and one of a number of osteogenic proteins shown to induce bone and cartilage formation, and to play an important role in developmental processes, including cell proliferation, differentiation, apoptosis and morphogenesis.BMPs act through binding with a receptor complex consisting of type I and type II serine/threonine kinases, resulting ultimately in the activation of the Smad protein and mitogen-activated protein kinase (MAPK) signaling pathways. Several antagonist proteins, including, noggin, chordin, gremlin and follistatin, are responsible for modulating the signaling effects of BMPs, through the binding and blocking of receptor ligands, thereby preventing activation.BMP-7 is involved during ontogeny of the kidney with prominent expression in renal tubules. Experimental diabetic nephropathy indicates BMP-7 has antifibrogenic properties and appears to act as an antagonist to TGF-Beta (Wang et al. 2001 & Godin et al. 1998).

WB, IHC-P, ELISA

ELISA: 0.5 µg/ml, WB: 0.1 - 0.2 µg/ml

Human

Recombinant human BMP-7.

Rabbit

Polyclonal

IgG

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human BMP-7 antibody recognizes the disulphide-linked homodimeric cysteine knot protein known as human Bone Morphogenetic Protein 7 (BMP-7) or Osteogenic protein 1 (OP-1). BMP-7 is a member of the transforming growth factor beta (TGF-B) superfamily and one of a number of osteogenic proteins shown to induce bone and cartilage formation, and to play an important role in developmental processes, including cell proliferation, differentiation, apoptosis and morphogenesis.BMPs act through binding with a receptor complex consisting of type I and type II serine/threonine kinases, resulting ultimately in the activation of the Smad protein and mitogen-activated protein kinase (MAPK) signaling pathways. Several antagonist proteins, including, noggin, chordin, gremlin and follistatin, are responsible for modulating the signaling effects of BMPs, through the binding and blocking of receptor ligands, thereby preventing activation.BMP-7 is involved during ontogeny of the kidney with prominent expression in renal tubules. Experimental diabetic nephropathy indicates BMP-7 has antifibrogenic properties and appears to act as an antagonist to TGF-Beta (Wang et al. 2001 & Godin et al. 1998).

BMP-7, Bone morphogenetic protein 7, OP-1, OP1, Osteogenic protein 1