Anti-c-Myb Antibody [MYB286] - BSA and Azide free (A252627)

Anti-c-Myb Antibody [MYB286] - BSA and Azide free

Mouse monoclonal [MYB286] antibody to c-Myb.

The highly leukemogenic avian retrovirus E26 contains two oncogenes, v-Myb and v-Ets, which are expressed together as a fusion protein. The cellular homolog of v-Myb, designated c-Myb, encodes a transcription factor. Deletion or disruption of a negative regulatory domain mapping within the carboxy-terminal domain of c-Myb results in enhanced transactivating capacity and in parallel, leads to activation of its ability to transform hemopoietic cells. c-Myb is expressed preferentially, but not exclusively, in immature hemopoietic cells and its expression decreases as cells differentiate.

Human

Synthetic peptide corresponding to amino acids 119-135 of c-Myb onco protein, coupled to KLH.

RRKVEQEGYPQESSKAG

Mouse

Monoclonal

MYB286

IgG1

kappa

Protein A/G chromatography.

1 mg/ml

~75 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-c-Myb Antibody [MYB286] (A249447).

MYB, Proto-oncogene c-Myb, Transcriptional activator Myb