Anti-CCR5 Antibody (A283227)

Anti-CCR5 Antibody

Goat polyclonal antibody to CCR5.

This antibody recognises human CD195, also known as C-C chemokine receptor type 5, CCR5 or C-C CKR-5. CD195 is a 353 amino acid ~37 kDa multiple pass transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, preferentially expressed by a subset of memory Th1 (type 1 helper T) cells. Goat anti human CD195 antibody binds to an epitope within the N-terminal region of CD195.CD195 acts as a high-affinity receptor for several chemotactic chemokines, including MIP-1 alpha (macrophage inflammatory protein 1 alpha), MIP-1 beta, and RANTES (regulated on activation normal T expressed and secreted protein). CD195 is also a major co-receptor for HIV-1 infection, with variations in the CD195 gene, influencing the rate of progression into AIDS. Goat anti human CD195 antibody is suitable for use in immunocytochemistry on human peripheral blood leucocytes.

WB, IHC-P, ELISA, IHC-Fr

ELISA: 1:50,000, IHC-P: 1:300, WB: 1:1,000

Human, Macaque

Synthetic peptide sequence YQVSSPIYDINYYTSEPCQKINVKQIAA corresponding to amino acids 3-30 within the N-terminus of human CD195.

YQVSSPIYDINYYTSEPCQKINVKQIAA

Goat

Polyclonal

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.1% BSA and 0.1% Sodium Azide.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Goat anti Human CD195 antibodyrecognizes human CD195, also known as C-C chemokine receptor type 5, CCR5 or C-C CKR-5. CD195 is a 353 amino acid ~37 kDa multiple pass transmembrane glycoprotein and member of the G-protein coupled receptor 1 family, preferentially expressed by a subset of memory Th1 (type 1 helper T) cells. Goat anti human CD195 antibody binds to an epitope within the N-terminal (NT) region of CD195.CD195 acts as a high-affinity receptor for several chemotactic chemokines, including MIP-1 alpha (macrophage inflammatory protein 1 alpha), MIP-1 beta, and RANTES (regulated on activation normal T expressed and secreted protein). CD195 is also a major co-receptor for HIV-1 infection, with variations in the CD195 gene, influencing the rate of progression into AIDS (Choe et al. 1996). Goat anti human CD195 antibody is suitable for use in immunocytochemistry on human peripheral blood leucocytes.

C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CD195, CHEMR13, CMKBR5, HIV-1 fusion coreceptor