Anti-CD1 Antibody [76-7-4] (PE) (A279512)

Anti-CD1 Antibody [76-7-4] (PE)

Mouse monoclonal [76-7-4] antibody to CD1 (PE).

This antibody recognises a porcine homologue of the human CD1 cell surface receptor. CD1 is a member of the immunoglobulin superfamily. While it is structurally similar to the MHC class I receptor CD1 differs functionally by presenting lipid antigens to T cells. To date, five classes of the CD1 genes have been identified across different mammalian species, namely CD1A, CD1B, CD1C, CD1D, and CD1E. In swine various tissues express CD1C even though its gene has been reported to carry a loss-of-function mutation. CD1 is predominantly found on dendritic cells, macrophages, monocytes, and thymocytes.

Flow Cytometry: Neat - 1:5, Use 10µl of the suggested working dilution to label 1x10⁶ cells in 100µl

Porcine

Fresh dd miniature swine thymocytes.

Mouse

Monoclonal

76-7-4

Precipitation and chromatography.

100 µg/ml

Liquid

Supplied in Phosphate Buffered Saline with Sucrose and <0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! This product is photosensitive and should be protected from light.

Mouse anti Pig CD1 antibody, clone 76-7-4 recognizes a porcine homologue of the human CD1 cell surface receptor. CD1 is a member of the immunoglobulin superfamily. While it is structurally similar to the MHC class I receptor CD1 differs functionally by presenting lipid antigens to T cells (Germain & Margulies, 1993).To date, five classes of the CD1 genes have been identified across different mammalian species, namely CD1A, CD1B, CD1C, CD1D, and CD1E (Brigl & Brenner, 2004). In swine various tissues express CD1C even though its gene has been reported to carry a loss-of-function mutation (Eguchi-Ogawa et al. 2007). CD1 is predominantly found on dendritic cells, macrophages, monocytes, and thymocytes (Chun et al. 1999).

This product is for research use only. It is not intended for diagnostic or therapeutic use.