Anti-CD1b Antibody [100-1A5] - BSA and Azide free (A254354)

Anti-CD1b Antibody [100-1A5] - BSA and Azide free

Mouse monoclonal [100-1A5] antibody to CD1b.

The Mouse monoclonal antibody recognizes CD1b, a 44kDa type I glycoprotein associated with beta2-microglobulin (Workshop IV; Code T015). It is expressed on dendritic cells, Langerhans cells, thymocytes, and T acute lymphoblastic leukemia cells. The CD1 multigene family encodes five forms of the CD1 T-cell surface glycoprotein in human, designated CD1A, 1B, 1C, 1D and 1E. CD1, a type 1 membrane protein, has structural similarity to the MHC class I antigen and has been shown to present lipid antigens for recognition by T lymphocytes. Constitutive endocytosis of CD1B molecules and the differential sorting of MHC class II from lysosomes separate peptide- and lipid antigen-presenting molecules during dendritic cell maturation. CD1B is also expressed in interdigitating cells.

Flow Cytometry, IF, Functional Studies

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human

Stimulated human leukocytes.

Mouse

Monoclonal

100-1A5

IgM

Protein A/G chromatography.

1 mg/ml

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-CD1b Antibody [100-1A5] (A251077).

T-cell surface glycoprotein CD1b