Anti-CEACAM1 Antibody [CEACAM1/4843] (A314780)

Anti-CEACAM1 Antibody [CEACAM1/4843]

Mouse monoclonal [CEACAM1/4843] antibody to CEACAM1.

Carcinoembryonic antigen (CEA) is one of the most commonly used tumor markers in serum immunoassay determinations of carcinoma. Members of the CEACAM (carcinoembryonic antigen-related cell adhesion molecule) family contain a single N domain, with structural homology to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constantlike A and/or B domains. CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1), also known as BGP or BGP1, is a 526 amino acid protein that exists as seven alternatively spliced isoforms, some of which localize to the cell membranes, while others are secreted. One of several members of the CEACAM family, CEACAM1 contains one Ig-like V-type domain and three Ig-like C2-type domains and is thought to play a role in a variety of cellular activities, including angiogenesis, apoptosis, arrangement of tissue threedimensional structure and modulation of innate and adaptive immune responses. Additionally, CEACAM1 is underexpressed in colorectal cancers, suggesting a role in tumor suppression.

Human: colon, endometrium, liver or hepatic carcinoma tissues.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 50-250) of human CEACAM1 protein. The exact sequence is proprietary.

Mouse

Monoclonal

CEACAM1/4843

kappa

Protein A/G chromatography.

200 µg/ml

90-180 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

BGP, BGP-1, BGP1, Biliary glycoprotein 1, Carcinoembryonic antigen-related cell adhesion molecule 1, CD66a