Anti-Complement Factor B Antibody [032B-32.15.1 (10-09)] (A278899)

Anti-Complement Factor B Antibody [032B-32.15.1 (10-09)]

Mouse monoclonal [032B-32.15.1 (10-09)] antibody to Complement Factor B.

This antibody recognises the Bb fragment of 90 kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change which enables complement factor D to cleave the N-terminal of complement factor B, the Ba subunit, leaving the 63 kDa Bb subunit associated with C3b and forming C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes. Conversely, Ba inhibits lymphocyte proliferation.

Flow Cytometry, ELISA, IHC-Fr, WB

Human

Human Factor B.

Mouse

Monoclonal

032B-32.15.1 (10-09)

IgG1

Protein A affinity chromatography of ascites.

Liquid

Supplied in Borate Buffered Saline with 0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Human complement factor B antibody, clone 032B-32.15.1 (10-09) recognises the Bb fragment of 90 kDa human complement factor B, present in blood serum. C3b associates with complement factor B, inducing conformational change which enables complement factor D to cleave the N-terminal of complement factor B, the Ba subunit, leaving the 63 kDa Bb subunit associated with C3b and forming C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes. Conversely, Ba inhibits lymphocyte proliferation.

BF, BFD, C3/C5 convertase, CFB, GBG, Glycine-rich beta glycoprotein, PBF2, Properdin factor B