Recombinant Anti-COX2 Antibody [COX2/7803R] (A314810)

Anti-COX2 Antibody [COX2/7803R]

Recombinant rabbit monoclonal [COX2/7803R] antibody to COX2.

Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate molecule in formation of the prostaglandins. Cyclooxygenase-1 (Cox-1) and cyclooxygenase-2 (Cox-2) are prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA). Cox-1 and Cox-2 are isozymes of prostaglandin-endoperoxidase synthase (PTGS). Cox-1 is constitutively expressed in most tissues and is thought to serve in general housekeeping functions. Cox-2 is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatory drugs, NSAIDs. COX2 expression is significantly increased in 85-90% of human colorectal adenocarcinomas whereas levels of COX-1 are not changed.

Human colon or lung carcinoma tissue (IHC).

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 400-604) of human PTGS2 protein. The exact sequence is proprietary.

Rabbit

Monoclonal

COX2/7803R

kappa

Protein A/G chromatography.

200 µg/ml

70-72 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

COX-2, Cyclooxygenase-2, PGH synthase 2, PGHS-2, PHS II, Prostaglandin G/H synthase 2, Prostaglandin H2 synthase 2, Prostaglandin-endoperoxide synthase 2, PTGS2