Rabbit anti GATA1 antibody recognizes GATA1, also known as GATA binding factor 1. The protein is a member of the GATA family of transcription factors, which has received its name from binding DNA containing the GATA consensus motif 5'-[AT]GATA[AG]-3' (uniprot P15976).GATA1 acts as an erythroid transcription factor by regulating erythroid-specific genes. In addition to that, GATA1 has also been implied to play a role in regulating differentiation of other hematopoietic lineages (including mast cells and megakaryocytes) and endothelial cells (Orkin 1992).GATA1 alterations have been implicated in a variety of diseases, including acute megakaryoblastic leukemia (AMKL) associated with Trisomy 21 and thrombocytopenia (Ciovacco et al. 2008).
Applications
WB, IHC-P, IF, ICC
Reactivity
Human, Mouse
Immunogen
N-terminal truncated human recombinant protein.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Purification
Affinity chromatography.
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 30% Glycerol, 1mg/ml BSA, and < 0.1% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
