This antibody recognises zinc finger protein GLI1, also known as glioma-associated oncogene.GLI1 is a protein that functions as a transcription factor and an effector of hedgehog (Hh) signaling. GLI transcription factors activate/inhibit transcription by binding to GLI responsive genes and interacting with the transcription complex. During embryonic development, GLI proteins play a role in proliferation and cell fate determination (Ruiz i Altaba, 1999).
Applications
WB
Dilutions
WB: 1:500 - 1:2,000
Reactivity
Human
Immunogen
A peptide derived from within the C-terminus of human GLI1.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
Lot Specific
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 0.035% Sodium Azide and 30% Glycerol.
Storage
Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.
General Notes
Rabbit anti Human GLI1 antibody recognizes zinc finger protein GLI1,also known asglioma-associated oncogene.GLI1 is aproteinthat functions as a transcription factor and an effector ofhedgehog (Hh) signaling. GLItranscription factorsactivate/inhibit transcription by binding to GLI responsive genes and interacting with the transcription complex (Callahan et al. 2004). During embryonic development, GLI proteins play a role inproliferation and cell fate determination (Ruiz i Altaba, 1999).
Synonyms
GLI, Glioma-associated oncogene, Oncogene GLI, Zinc finger protein GLI1
