This antibody recognises interleukin-17B (IL-17B) also known as cytokine Zcyto7, IL-20 and neuronal interleukin-17-related factor. IL17B is a member of the IL-17 superfamily of cytokines and is expressed in a wide range of tissues and cell types including human pancreas, small intestine, chondrocytes and neurons. There is limited information about the biological functions of IL17B, but it is known to act as a proinflammatory cytokine inducing TNFa and IL-1ß production in THP-1 cells and stimulating neutrophil infiltration (Bie et al. 2017, Liu et al. 2020). IL-17B has also been reported to induce the migration of CXCR4+ or CXCR5+ germinal center B cells to CXCL12 and CXCL13.
E. coli derived recombinant human interleukin-17B.
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Conjugate
Unconjugated
Concentration
1 mg/ml after reconstitution.
Product Form
Lyophilized
Reconstitution
Reconstitute with 0.1 ml of distilled water.
Formulation
Supplied in Phosphate Buffered Saline.
Storage
Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Rabbit anti Human interleukin-17B antibody recognizes interleukin-17B (IL-17B) also known as cytokine Zcyto7, IL-20 and neuronal interleukin-17-related factor. IL17B is a member of the IL-17 superfamily of cytokines and is expressed in a wide range of tissues and cell types including human pancreas, small intestine, chondrocytes and neurons. There is limited information about the biological functions of IL17B, but it is known to act as a proinflammatory cytokine inducing TNFa and IL-1ß production in THP-1 cells and stimulating neutrophil infiltration (Bie et al. 2017, Liu et al. 2020). IL-17B has also been reported to induce the migration of CXCR4+ or CXCR5+ germinal center B cells to CXCL12 and CXCL13 (Bie et al. 2017).
