Recombinant Anti-INSM1 Antibody [rINSM1/6287] - BSA and Azide free (A316570)

Anti-INSM1 Antibody [rINSM1/6287] - BSA and Azide free

Recombinant mouse monoclonal [rINSM1/6287] antibody to INSM1.

Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95% of lung small cell carcinoma and 91% of lung large cell neuroendocrine carcinoma, compared with 75% and 78% with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56). INSM1 stains 100% of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3% of adenocarcinomas and 4% of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.

Human pancreas or neuroendocrine tumor.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 81-125) corresponding to the N-terminus of human INSM1.

Mouse

Monoclonal

rINSM1/6287

kappa

Protein A/G chromatography.

1 mg/ml

58 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

IA1, Insulinoma-associated protein 1, Zinc finger protein IA-1