Recombinant rabbit monoclonal [LMO2/3147R] antibody to LMO2.
Specificity
The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. It has a particular function in normal and lymphatic endothelial cells involving the regulation of angiogenesis and lymph-angiogenesis. Immunohistochemical studies have also demonstrated expression of LMO2 in both normal germinal center B-cells and germinal center-derived B-cell lymphomas, including follicular lymphoma and diffuse large B-cell lymphoma. The use of anti-LMO2 is valuable as a tool in the identification of lymphomas of B-cell origin. LMO2 is useful in differentiating follicular lymphoma (LMO2+) from nodal marginal zone lymphoma (LM02-). It also is positive in Hodgkins lymphomas.
Immunofluorescent analysis of K562 cells stained with Anti-LMO2 Antibody [LMO2/3147R] followed by Goat Anti-Rabbit IgG (CF® 488) (Green). Membrane labeled with Phalloidin (Red).
SDS-PAGE analysis of Anti-LMO2 Antibody [LMO2/3147R] under non-reduced and reduced conditions; showing intact IgG and intact heavy and light chains, respectively. SDS-PAGE analysis confirms the integrity and purity of the antibody.
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