Mouse anti human LYVE-1, clone 4G1 recogniszs human LYVE-1, otherwise known as hyaluronic acid receptor, a type I integral membrane glycoprotein and member of the Link protein superfamily, expressed on the cell surface of both normal and neoplastic lymphatic endothelial cells. LYVE-1 acts a major receptor for the glycosaminoglycan hyaluronan (HA) in both its soluble and immobilized forms.The binding of LYVE-1 to HA on lymph vessel walls and not to the endothelium of blood vessels, makes LYVE-1 a powerful marker for the identification of lymphatic endothelial cells, and for distinguishing between lymphatic vessels and blood vasculature (Koukourakis et al. 2005).
Applications
WB, ELISA
Reactivity
Human
Immunogen
Recombinant human LYVE-1 (amino acids 25-235) purified from Escherichia coli.
Host
Mouse
Clonality
Monoclonal
Clone ID
4G1
Isotype
IgG2b
Conjugate
Unconjugated
Purification
Protein G chromatography.
Concentration
1 mg/ml
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 10% Glycerol and 0.02% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
Cell surface retention sequence-binding protein 1, CRSBP-1, CRSBP1, Extracellular link domain-containing protein 1, HAR, Hyaluronic acid receptor, Lymphatic vessel endothelial hyaluronic acid receptor 1, XLKD1
