Anti-MAGE 1 Antibody [MA454] (A249274)

Anti-MAGE 1 Antibody [MA454]

Mouse monoclonal [MA454] antibody to MAGE 1.

This antibody recognizes a protein of 42-46kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

IHC-P: 1-2 µg/ml

Human, Rat, Canine

Recombinant full-length human MAGE-A1 protein.

Mouse

Monoclonal

MA454

IgG1

kappa

Protein A/G chromatography.

200 µg/ml

42-46 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-MAGE 1 Antibody [MA454] - BSA and Azide free (A252454).

Antigen MZ2 E, Antigen MZ2-E, Cancer/testis antigen 1.1, cancer/testis antigen family 1, member 1, CT1.1, MAGA1_HUMAN, MAGE 1 antigen, MAGE-1 antigen, MAGE1, MAGE1A, MAGEA1, Melanoma antigen 1, Melanoma antigen family A 1, Melanoma antigen family A 1 (directs expression of antigen MZ2 E), Melanoma antigen MAGE 1, Melanoma associated antigen 1, Melanoma associated antigen MZ2 E, Melanoma-associated antigen 1, MGC9326