Anti-MDM2 Antibody [SMP14] (A281750)

Anti-MDM2 Antibody [SMP14]

Mouse monoclonal [SMP14] antibody to MDM2.

This antibody recognises the ~90 kDa MDM2 protein, which forms a complex with p53 leading to p53 inhibition.MDM2 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI.MDM2 is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer.

IHC-P, IHC-Fr, IP, IHC-R

IHC-P 1: 1:200 - 1:500

Human, Mouse

Synthetic peptide sequence CSRPSTSSRRRAISE corresponding to amino acids 154-167 of human MDM2.

CSRPSTSSRRRAISE

Mouse

Monoclonal

SMP14

IgG1

Protein A affinity chromatography of tissue culture supernatant.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti MDM2 antibody, clone SMP14 recognizes the ~90 kDa MDM2 protein, which forms a complex with p53 leading to p53 inhibition.MDM2 also acts to stimulate cell proliferation via its induction of transcription factors such as E2F1 and DPI.MDM2 is over expressed in a range of human malignancies, including soft tissue sarcomas, breast cancer and bladder cancer.

Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2, RING-type E3 ubiquitin transferase Mdm2