Anti-MMP7 Antibody (A320058)

Anti-MMP7 Antibody

Goat polyclonal antibody to MMP7.

This antibody recognises matrix metalloproteinase 7 (MMP7), a ~30 kDa member of the MMP family. MMP's are secreted as inactive zymogens which are activated when proteolytically cleaved by extracellular proteinases. They are involved in processes such as embryonic development, reproduction and tissue remodelling where they breakdown the extracellular matrix. This action is also exploited by diseases processes including arthritis and metastasis. MMP7 degrades casein, fibronectin, gelatin types I, III, IV, V, and activates procollagenase. This metalloproteinase has been identified as an activator of the Notch signalling pathway, and is also involved in wound healing and the regulation of defensins in intestinal mucosa.

WB, ELISA

ELISA: 1:64,000, WB: 0.03 - 0.1 µg/ml

Human

A peptide sequence of C-QKLYGKRSNSRKK corresponding to the C-terminus of MMP7 (NP_002414.1).

C-QKLYGKRSNSRKK

Goat

Polyclonal

500 µg/ml

Approximately 28 kDa in human breast, ovary and placenta cell lysates. A minimum incubation time of 1 hour is recommended with this antibody.

Liquid

Supplied in TRIS Buffered Saline, 0.5% BSA and 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Matrilysin, Matrin, Matrix metalloproteinase-7, MMP-7, MPSL1, Pump-1 protease, PUMP1, Uterine metalloproteinase