Recombinant Anti-NCAM1 Antibody [rNCAM1/8580] (A315377)

Anti-NCAM1 Antibody [rNCAM1/8580]

Recombinant mouse monoclonal [rNCAM1/8580] antibody to NCAM1.

This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.

Human cerebellum, pancreas or neuroblastoma.

IHC: 1-2 µg/ml

Human

Recombinant human NCAM1 protein.

Mouse

Monoclonal

rNCAM1/8580

Protein A/G chromatography.

200 µg/ml

180 kDa / 145 kDa / 125 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

CD56, N-CAM-1, NCAM, NCAM-1, Neural cell adhesion molecule 1