Anti-NLRX1 Antibody (A320095)

Anti-NLRX1 Antibody

Goat polyclonal antibody to NLRX1.

This antibody recognises NLR family member X1 (NLRX1), also known as caterpiller protein 11.3, NOD26, NOD5, and NOD9.NLRX1 is a member of the NLR family of pattern recognition receptors (PRRs), but is an atypical member due to its structure. For example, it appears to be the only PRR family member with the ability to localize to mitochondria. However, NLRX1 appears to be ubituitously expressed in human cells, and appears to have different functions depending on cell type. NLRX1 appears to be a negative regulator of immune signaling during microbial infection, cancer, and autoimmune disease. Consistent with mitochondrial localization, NLRX1 regulates the function of mitochondria during apoptosis and injury in the presence of TNF-alpha.

WB: 1 µg/ml - 3 µg/ml

Human

A peptide sequence of C-NFSGETLDSTDPSN from the internal region of the protein sequence according to NP_078894.2; NP_733840.1.

C-NFSGETLDSTDPSN

Goat

Polyclonal

IgG

Approximately 100 kDa in cell lysates

Liquid

Supplied in TRIS Buffered Saline, 0.5% BSA and 0.02% Sodium Azide.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Goat anti NLRX1 antibody recognizes NLR family member X1 (NLRX1), also known as caterpiller protein 11.3, NOD26, NOD5, and NOD9.NLRX1 is a member of the NLR family of pattern recognition receptors (PRRs), but is an atypical member due to its structure (Nagai-Singer et al. 2019). For example, it appears to be the only PRR family member with the ability to localize to mitochondria (Chu et al. 2019). However, NLRX1 appears to be ubituitously expressed in human cells, and appears to have different functions depending on cell type (Nagai-Singer et al. 2019). NLRX1 appears to be a negative regulator of immune signaling during microbial infection, cancer, and autoimmune disease (Kastelberg et al. 2020). Consistent with mitochondrial localization, NLRX1 regulates the function of mitochondria during apoptosis and injury in the presence of TNF-alpha (Singh et al. 2019).

Caterpiller protein 11.3, CLR11.3, NLR family member X1, NOD5, NOD9, Nucleotide-binding oligomerization domain protein 5, Nucleotide-binding oligomerization domain protein 9