Anti-Noxa Antibody (A283002)

Anti-Noxa Antibody

Rabbit polyclonal antibody to Noxa.

This antibody recognises mouse Noxa, an ~11 kDa member of the BH3-only proapoptotic protein family. Noxa is localized to the mitochondria and is a transcriptional target of p73, p53 and BH3-only proteins. It is thought to induce apoptosis when activated, lowering the activity of anti-apoptotic Bcl-2-like proteins. It can be upregulated by mitogenic activation, independently of p53. In humans, along with Mcl-1 it is thought to form a selective pathway that restrains lymphocyte proliferation.

WB, IHC-P

WB: 0.5 - 1 µg/ml

Mouse, Human, Rat

Synthetic peptide corresponding to the N-terminus of mouse NOXA.

Rabbit

Polyclonal

IgG

Approximately 11 kDa in human stomach cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Murine Noxa antibody recognises murine Noxa, an ~11 kDa member of the BH3-only proapoptotic protein family. Noxa is localized to the mitochondria and is a transcriptional target of p73, p53 and BH3-only proteins. It is thought to induce apoptosis when activated, lowering the activity of anti-apoptotic Bcl-2-like proteins. It can be upregulated by mitogenic activation, independently of p53. In humans, along with Mcl-1 it is thought to form a selective pathway that restrains lymphocyte proliferation.

Immediate-early-response protein APR, Phorbol-12-myristate-13-acetate-induced protein 1, PMA-induced protein 1, PMAIP1, Protein Noxa