Anti-Orai3 Antibody (A283139)

Anti-Orai3 Antibody

Rabbit polyclonal antibody to Orai3.

This antibody recognises the N-terminal region of human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family.Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2.Rabbit anti Human ORAI3 antibody (AHP1496) is not expected to cross react with either ORAI1 or ORAI2.

WB, IHC-Fr

IHC-Fr: 10 µg/ml, WB: 1 - 2 µg/ml

Human, Rat, Mouse

A peptide corresponding to 15 amino acids near the N-terminus of human ORAI3.

Rabbit

Polyclonal

IgG

Approximately 35 kDa in A20 cell lysates.

Liquid

Supplied in Phosphate Buffered Saline with 0.02% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human ORAI3 antibody recognizes the N-terminal region of human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kDa multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2.Rabbit anti Human ORAI3 antibody ( AHP1496) is not expected to cross react with either ORAI1 or ORAI2.

Protein orai-3, TMEM142C, Transmembrane protein 142C