Anti-PDHA1 Antibody (A283816)

Anti-PDHA1 Antibody

Rabbit polyclonal antibody to PDHA1.

This antibody recognises pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, also known as PDHE1-A type 1 and PHE1A. The PDHA1 gene encodes part of the mitochondrial pyruvate dehydrogenase (PDH) complex, which converts pyruvate to acetyl-CoA and CO2. PDHA1 deficiency leads to mitochondrial dysfunction, and is associated with poor outcome in multiple cancer types. The gene encoding PDHA1 is located on the X-chromosome, and mutations result in metabolic disorders, intellectual disability and early death.

WB, IHC-P

IHC-P: 1:50 - 1:200, WB: 1:500 - 1:2,000

Human, Rat, Mouse

Recombinant protein of human PDHA1.

Rabbit

Polyclonal

IgG

Liquid

Supplied in Phosphate Buffered Saline with 0.05% ProClin 300 and 50% Glycerol.

Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti PDHA1 antibody recognizes pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, also known as PDHE1-A type 1 and PHE1A. The PDHA1 gene encodes part of the mitochondrial pyruvate dehydrogenase (PDH) complex, which converts pyruvate to acetyl-CoA and CO2. PDHA1 deficiency leads to mitochondrial dysfunction, and is associated with poor outcome in multiple cancer types (Song et al. 2018). The gene encoding PDHA1 is located on the X-chromosome, and mutations result in metabolic disorders, intellectual disability and early death (Yoshida et al. 2017).

PDHE1-A type I, PHE1A, Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial