Anti-Smad3 Antibody (A283129)

Anti-Smad3 Antibody

Rabbit polyclonal antibody to Smad3.

This antibody recognises Mothers against decapentaplegic homolog 3 (SMAD3), a 50 kDa transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase,SMAD3 functions in cell proliferation, differentiation and development. Upon stimulation, SMAD3 oligomerizes with SMAD4 and translocates into the nucleus where it binds to DNA and transcription factors. SMAD3 activity induces differentiation of selected neuronal subtypes at the expense of other subtypes.Defects in SMAD3 may be a cause of colorectal cancer (Sjöblom et al. 2006).

WB, IHC-P, ELISA

ELISA: 1:25,000 - 1:100,000, IHC-P: 2.5 µg/ml, WB: 1:2,000 - 1:20,000

Human, Mouse, Pig, Rat, Amphibia, Zebrafish, Bovine, Chicken

Synthetic peptide corresponding to amino acids 417-425 of human SMAD3 protein.

PSIRCSSVS

Rabbit

Polyclonal

IgG

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Rabbit anti Human SMAD3 antibody recognizes Mothers against decapentaplegic homolog 3 (SMAD3), a 50 kDa transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase, SMAD3 functions in cell proliferation, differentiation and development. Upon stimulation, SMAD3 oligomerizes with SMAD4 and translocates into the nucleus where it binds to DNA and transcription factors. SMAD3 activity induces differentiation of selected neuronal subtypes at the expense of other subtypes.Defects in SMAD3 may be a cause of colorectal cancer (Sjöblom et al. 2006).

hMAD-3, hSMAD3, JV15-2, MAD homolog 3, Mad3, MADH3, Mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, SMAD 3, SMAD family member 3