Anti-T-bet / Tbx21 Antibody [TBX21/6724] (A315712)

Anti-T-bet / Tbx21 Antibody [TBX21/6724]

Mouse monoclonal [TBX21/6724] antibody to T-bet / Tbx21.

T helper (Th) lymphocytes differentiate into two unique subsets, Th1 and Th2, which differ both in function and in the cytokines they secrete. Th1 and Th2 cytokines promote the growth and differentiation of their subset, and inhibit the growth and differentiation of the opposing subset. T-bet (T-box expressed in T cells) is a Th1-specific T-box transcription factor that controls the expression of the Th1 cytokine, IFN-g. T-bet also converts effector Th2 cells into the opposing Th1 subset. T-bet is selectively expressed in Th1 cells. The level of T-bet expression is increased by signals mediated by the T cell receptor (TCR). IL-12 also induces an increase in the level of T-bet. T-bet was originally isolated from nuclear extracts of resting and PMA/ionomycin-activated AE7 cells. It is expressed in low levels in AE7 cells, and in increased levels in stimulated AE7.

Human tonsil, non-Hodgkin s lymphoma or spleen. T-cell specific.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human TBX21 protein. The exact sequence is proprietary.

Mouse

Monoclonal

TBX21/6724

kappa

Protein A/G chromatography.

200 µg/ml

62 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

T bet, T box 21, T box expressed in T cells, T box protein 21, T box transcription factor TBX21, T cell specific T box transcription factor, T cell specific T box transcription factor T bet, T PET, T-box protein 21, T-box transcription factor TBX21, T-cell-specific T-box transcription factor T-bet, TBET, TBLYM, TBX 21, Tbx21, TBX21_HUMAN, TPET, Transcription factor TBLYM