Anti-T-bet / Tbx21 Antibody [TBX21/6724] - BSA and Azide free (A317096)

Anti-T-bet / Tbx21 Antibody [TBX21/6724] - BSA and Azide free

Mouse monoclonal [TBX21/6724] antibody to T-bet / Tbx21.

T helper (Th) lymphocytes differentiate into two unique subsets, Th1 and Th2, which differ both in function and in the cytokines they secrete. Th1 and Th2 cytokines promote the growth and differentiation of their subset, and inhibit the growth and differentiation of the opposing subset. T-bet (T-box expressed in T cells) is a Th1-specific T-box transcription factor that controls the expression of the Th1 cytokine, IFN-g. T-bet also converts effector Th2 cells into the opposing Th1 subset. T-bet is selectively expressed in Th1 cells. The level of T-bet expression is increased by signals mediated by the T cell receptor (TCR). IL-12 also induces an increase in the level of T-bet. T-bet was originally isolated from nuclear extracts of resting and PMA/ionomycin-activated AE7 cells. It is expressed in low levels in AE7 cells, and in increased levels in stimulated AE7.

Human tonsil, non-Hodgkin s lymphoma or spleen. T-cell specific.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human TBX21 protein. The exact sequence is proprietary.

Mouse

Monoclonal

TBX21/6724

kappa

Protein A/G chromatography.

1 mg/ml

62 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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