Recombinant Anti-TdT Antibody [rDNTT/6909] - BSA and Azide free (A278472)

Anti-TdT Antibody [rDNTT/6909] - BSA and Azide free

Recombinant mouse monoclonal [rDNTT/6909] antibody to TdT.

Terminal deoxynucleotidyl transferase (TdT) is an unusual deoxynucleotide polymerizing enzyme with a molecular weight of about 58 kDa found normally only in B- and T-cell lymphoblasts/prelymphocytes. TdT generates antigen receptor diversity by synthesizing non-germ line elements (N-regions) at the junctions of rearranged Ig heavy chain and T cell receptor gene segments. Rare TdT-positive cells are regularly detected in thymus and bone marrow. Typically, TdT expression in the thymus is very variable from cell to cell since it is rapidly decreased in more mature T-cells. TdT-positive cells may occasionally be found in tonsils, lymph nodes and extranodal lymphoid tissue. Immunohistochemical detection of TdT has value in classification of malignant lymphomas and acute leukemias, particularly for the identification of pre-B and pre-T acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL).

ELISA, IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant fragment, around amino acids 1-100, of human TdT protein. The exact sequence is proprietary.

Mouse

Monoclonal

rDNTT/6909

IgG1

Protein A/G chromatography.

1 mg/ml

58 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-TdT Antibody [rDNTT/6909] (A277884).

DNA nucleotidylexotransferase, DNTT, Terminal addition enzyme, Terminal deoxynucleotidyltransferase, Terminal transferase