Anti-TRAIL Antibody [2E5] (A278868)

Anti-TRAIL Antibody [2E5]

Mouse monoclonal [2E5] antibody to TRAIL.

This antibody recognises the 281 amino acid protein termed TNF related apoptosis-inducing ligand (TRAIL), also known as Apo2L.TRAIL is a cytotoxic protein closely related to Fas (CD95), which induces extensive apoptosis in a range of cell types. TRAIL induces apoptosis via the receptors DR4 and DR5. Most normal tissues are resistant to TRAIL induced apoptosis due to their expression of decoy receptors, DcR1 and DcR2, which antagonise TRAIL activity.TRAIL is expressed by cell lines, activated lymphocytes and on syncytiotrophoblast cells in first trimester pregnancy.This antibody neutralizes TRAIL activity.

WB, Flow Cytometry, Functional Assays

Human

Recombinant human CD253 (TRAIL) amino acids 95-281.

TSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG

Mouse

Monoclonal

2E5

IgG1

Protein A affinity chromatography of tissue culture supernatant.

1 mg/ml

Liquid

Supplied in Phosphate Buffered Saline.

Store undiluted at -20°C only. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.

Mouse anti Human CD253 antibody, clone 2E5 recognizes the 281 amino acid protein termed TNF related apoptosis-inducing ligand (TRAIL), also known as Apo2L.TRAIL is a cytotoxic protein closely related to Fas (CD95), which induces extensive apoptosis in a range of cell types. TRAIL induces apoptosis via the receptors DR4 and DR5. Most normal tissues are resistant to TRAIL induced apoptosis due to their expression of decoy receptors, DcR1 and DcR2, which antagonise TRAIL activity.TRAIL is expressed by cell lines, activated lymphocytes and on syncytiotrophoblast cells in first trimester pregnancy.This antibody neutralizes TRAIL activity.

Apo-2 ligand, Apo-2L, APO2L, CD253, Protein TRAIL, TNF-related apoptosis-inducing ligand, TNFSF10, Tumor necrosis factor ligand superfamily member 10