Anti-UBE2C Antibody [CPTC-UBE2C-1] (A248187)

Anti-UBE2C Antibody [CPTC-UBE2C-1]

Mouse monoclonal [CPTC-UBE2C-1] antibody to UBE2C.

The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. The first step requires the ATP-dependent activation of the Ub C-terminus and the assembly of multi-Ub chains by the Ub-activating enzyme known as the E1 component. The Ub chain is then conjugated to the Ubconjugating enzyme (E2) to generate an intermediate Ub-E2 complex. The Ub-ligase (E3) then catalyzes the transfer of Ub from E2 to the appropriate protein substrate. UBE2C, also designated UBCH10 in human, is an E2 ubiquitin conjugating enzyme for the anaphase promoting complex (APC), which coordinates mitosis and G1 by sequentially promoting the degradation of key cell-cycle regulators. UBE2C is overexpressed in many different types of cancers and may be a potential therapeutic target.

ELISA, IHC-P

IHC-P: 1-2 µg/ml

Human

Recombinant full-length human UBE2C protein.

Mouse

Monoclonal

CPTC-UBE2C-1

IgG2b

kappa

Protein A/G chromatography.

200 µg/ml

20 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-UBE2C Antibody [CPTC-UBE2C-1] - BSA and Azide free (A251370).

E2 ubiquitin-conjugating enzyme C, E3-independent) E2 ubiquitin-conjugating enzyme C, EC:2.3.2.24, UBCH10, Ubiquitin carrier protein C, Ubiquitin-conjugating enzyme E2 C, Ubiquitin-protein ligase C