Anti-Ubiquitin Antibody (A282896)

Anti-Ubiquitin Antibody

Sheep polyclonal antibody to Ubiquitin.

This antibody recognises ubiquitin, a 8.6 kDa cytoplasmic and nuclear protein highly conserved across species. Ubiquitin functions as a protein modifier which covalently attaches to lysines as either a monomer or as a lysine-linked polymer. Attachment as a Lys-48 polymer usually leads to the target protein undergoing proteolytic degradation. Attachment as a monomer does not result in degradation and may be linked to functions including maintenance of chromatin structure, regulation of gene expression, stress response and DNA repair.Ubiquitin can be detected in both normal and diseased brain tissues including the neurofibrillary tangles of Alzheimers disease, Lewy bodies in Parkinsons disease and Pick bodies in Pick’s disease.

ELISA: 1:100 - 1:2,000

Bovine

Native ubiquitin, purified from bovine erythrocytes to a purity >90% by SDS-PAGE.

Sheep

Polyclonal

IgG

Protein G affinity chromatography.

5 mg/ml

Liquid

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Sheep anti Bovine ubiquitin antibody recognizes ubiquitin, a 8.6 kDa cytoplasmic and nuclear protein highly conserved across species. Ubiquitin functions as a protein modifier which covalently attaches to lysines as either a monomer or as a lysine-linked polymer. Attachment as a Lys-48 polymer usually leads to the target protein undergoing proteolytic degradation. Attachment as a monomer does not result in degradation and may be linked to functions including maintenance of chromatin structure, regulation of gene expression, stress response and DNA repair.Ubiquitin can be detected in both normal and diseased brain tissues including the neurofibrillary tangles of Alzheimers disease, Lewy bodies in Parkinsons disease and Pick bodies in Pick’s disease.

Polyubiquitin-B, Polyubiquitin-C, UBB, UBC