Anti-beta Catenin Antibody (A283425)

Anti-beta Catenin Antibody

Rabbit polyclonal antibody to beta Catenin.

This antibody recognises catenin beta, also known as beta-catenin. Catenin beta is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Catenin beta also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete.Catenin beta binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in catenin beta are a cause of colorectal cancer, pilomatrixoma (PTR), medulloblastoma (MDB) and ovarian cancer. Three transcript variants encoding the same protein have been found for catenin beta (provided by RefSeq, Oct 2009).

WB: 1:400 - 1:1,000

Human, Mouse, Rat

A peptide corresponding to the C-terminus of human catenin beta.

Rabbit

Polyclonal

IgG

200 µg/ml

Approximately 100 kDa when run under reducing conditions

Liquid

Supplied in Phosphate Buffered Saline with 0.2% Gelatin and 0.1% Sodium Azide.

Store undiluted at 4°C. Do not freeze! Should this product contain a precipitate we recommend microcentrifugation before use.

Rabbit anti catenin beta antibody recognizes catenin beta, also known as beta-catenin. Catenin beta is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. Catenin beta also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete.Catenin beta binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in catenin beta are a cause of colorectal cancer, pilomatrixoma (PTR), medulloblastoma (MDB) and ovarian cancer. Three transcript variants encoding the same protein have been found for catenin beta (provided by RefSeq, Oct 2009).

Beta-catenin, Catenin beta-1, CTNNB, CTNNB1