Anti-CD105 Antibody [ENG/4750] (A314579)

$765

Mouse monoclonal [ENG/4750] antibody to CD105 for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-CD105 Antibody [ENG/4750]
Description
Mouse monoclonal [ENG/4750] antibody to CD105.
Specificity
CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
Applications
IHC-P
Positive Control
HeLa, A431 or HL-60 cells.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human, Monkey, Horse, Porcine, Rat
Immunogen
Recombinant extracellular fragment of human Endoglin protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
ENG/4750
Isotype
IgG1
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
200 µg/ml
Molecular Weight
80 kDa (Monomer) / 160 kDa (Homodimer)
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Synonyms
AI528660, AI662476, CD 105, CD105 antigen, EGLN_HUMAN, END, Endoglin, Eng, FLJ41744, HHT1, ORW, ORW1, Osler Rendu Weber syndrome 1, RP11 228B15.2, S-endoglin, SN6
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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