Anti-CD105 Antibody [ENG/4750] - BSA and Azide free
Description
Mouse monoclonal [ENG/4750] antibody to CD105.
Specificity
CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the TGF-beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues. Angiogenesis is a promising prognostic marker in a variety of tumors. Endoglin is a more specific and sensitive marker for tumor angiogenesis than CD31 or CD34, as it labels only newly-formed blood vessels and may serve as a prognostic marker for Prostate Adenocarcinoma, and cancers of the lung, stomach, breast, and brain.
Applications
IHC-P
Positive Control
HeLa, A431 or HL-60 cells.
Dilutions
IHC: 1-2 µg/ml
Reactivity
Human, Monkey, Horse, Porcine, Rat
Immunogen
Recombinant extracellular fragment of human Endoglin protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
ENG/4750
Isotype
IgG1
Light Chains
kappa
Conjugate
Unconjugated
Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
80 kDa (Monomer) / 160 kDa (Homodimer)
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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