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Anti-CDK5R1 Antibody

Rabbit polyclonal antibody to CDK5R1 from ABclonal (A0197).
Name: Anti-CDK5R1 Antibody
Description: Rabbit polyclonal antibody to CDK5R1.
Applications: WB, IHC
Dilutions: WB: 1:200 - 1:500, IHC: 1:50 - 1:100.
Reactivity: Human
Immunogen: A synthetic peptide of human CDK5R1.
Protein Length: 307
Host: Rabbit
Clonality: Polyclonal
Isotype: IgG
Conjugate: Unconjugated
Purification: Affinity purification.
Product Form: Liquid
Formulation: Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Function: p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution.
Tissue Specificity: Brain and neuron specific.
Sequence Similarities: Belongs to the cyclin-dependent kinase 5 activator family.
Post-Translational Modification: The p35 form is proteolytically cleaved by calpain, giving rise to the p25 form. P35 has a 5 to 10 fold shorter half-life compared to p25. The conversion results in deregulation of the CDK5 kinase: p25/CDK5 kinase displays an increased and altered tau phosphorylation in comparison to the p35/CDK5 kinase in vivo (By similarity).
Cellular Location: Cell membrane.

In the primary cortical neurons, p35 is present in the peripheries and nerve terminals.
UniProt: Q15078
Gene ID: 8851
Synonyms: CD5R1_HUMAN Antibody
CDK5 activator 1 Antibody
CDK5P35 Antibody
CDK5R Antibody
Cyclin dependent kinase 5 regulatory subunit 1 Antibody
Cyclin-dependent kinase 5 activator 1 Antibody
Cyclin-dependent kinase 5 regulatory subunit 1 Antibody
NCK 5A Antibody
Neuronal CDK5 activator Antibody
p23 Antibody
p25 Antibody
p35 Antibody
Regulatory partner for CDK5 kinase Antibody
Tau protein kinase II 23 kDa subunit Antibody
TPKII regulatory subunit Antibody
Information: Target information shown above is from the UniProt Consortium.
Western blot analysis of A2058 cell lysate using CDK5R1 antibody.
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.
Description: Rabbit polyclonal antibody to CDK5R1 (Q31)
Application: WB, IHC, IF
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide, corresponding to amino acids 1-54 of Human p35.

£165 – £283

Description: Rabbit polyclonal antibody to CDK5R1
Application: WB, IF
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from internal of human CDK5R1.

£180 – £234

Description: Rabbit polyclonal antibody to p23
Application: WB, IHC, ELISA
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human p23 around the non-phosphorylation site of S113.

£180 – £234

Description: Rabbit polyclonal antibody to p35
Application: WB, IHC, IF, ELISA
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthesized peptide derived from the N-terminal region of human p35.

£180 – £234

Please Note: Anti-CDK5R1 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | A0197
Size Price Quantity
100µl £243
200µl £372

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Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe