Anti-Clusterin Antibody [CLU/4729] - BSA and Azide free (A278140)

Mouse monoclonal [CLU/4729] antibody to Clusterin for IHC-P.

Alternative Formats and ConjugatesAlternative Formats

Freight Charges
Lead Time
4-6 Business Days
Telephone
+1 (314) 370-6046
Mon - Fri, 8am - 4pm AST
Email
orders@antibodies.com
Name
Anti-Clusterin Antibody [CLU/4729] - BSA and Azide free
Description
Mouse monoclonal [CLU/4729] antibody to Clusterin.
Specificity
Clusterin, also designated complement lysis inhibitor (CLI), apolipoprotein J (APOJ), sulfated glycoprotein 2 (SGP2), SP40 and testosterone-repressed prostate message 2 (TRPM2), is a secretory, heterodimeric glycoprotein that influences immune regulation, cell adhesion, transformation, lipid transportation, tissue remodeling, membrane recycling and cell-cell interactions. Clusterin is synthesized as a 449 amino acid polypeptide that is post-translationally cleaved at an internal bond between Arg 227 and Ser 228. Two subunits, α and β, are associated through disulfide bonds. The β subunit (also called ApoJα) corresponds to residues 23-227. The α subunit (also called ApoJβ) corresponds to residues 228-449. Overexpression of Clusterin appears to be more common in late stages of mammary tumor progression. Clusterin markedly influences β-Amyloid structure and neuritic toxicity in vivo and may influence Alzheimer s pathogenesis.
Applications
IHC-P
Dilutions
IHC-P: 1-2 µg/ml
Reactivity
Human
Immunogen
Recombinant fragment, around amino acids 150-300, of human Clusterin protein. The exact sequence is proprietary.
Host
Mouse
Clonality
Monoclonal
Clone ID
CLU/4729
Isotype
IgG2c
Light Chains
kappa
Conjugate

Unconjugated

Purification
Protein A/G chromatography.
Concentration
1 mg/ml
Molecular Weight
70 kDa (precursor) / 36-39 kDa (alpha) / 34-36 kDa (beta)
Product Form
Liquid
Formulation
Supplied in 10mM Phosphate Buffered Saline; without Sodium Azide and carrier free.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General Notes
This monoclonal antibody is also available in a different formulation with BSA and Sodium Azide - Anti-Clusterin Antibody [CLU/4729] (A277552).
Synonyms
40, AAG 4, AAG4, Aging associated protein 4, Aging-associated gene 4 protein, AI893575, APO J, Apo-J, APOJ, ApoJalpha, ApoJbeta, Apolipoprotein J, ApolipoproteinJ, CLI, CLU, CLU1, CLU2, Clusterin alpha chain, Clusterin beta chain, CLUS_HUMAN, Complement associated protein SP 40, Complement associated protein SP 40 40, Complement associated protein SP40, Complement cytolysis inhibitor, Complement cytolysis inhibitor a chain, Complement cytolysis inhibitor b chain, Complement lysis inhibitor, Complement-associated protein SP-40, D14Ucla3, Dimeric acid glycoprotein, Glycoprotein 80, Glycoprotein III, GP80, Ku70-binding protein 1, KUB 1, KUB1, MGC24903, NA1/NA2, RATTRPM2B, SGP 2, SGP2, SP 40, SP40, Sugp-2, Sulfated glycoprotein 2, Testosterone repressed prostate message 2, Testosterone-repressed prostate message 2, TRPM 2, TRPM-2, TRPM2, TRPM2B, Trpmb
Disclaimer
This product is for research use only. It is not intended for diagnostic or therapeutic use.
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