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Anti-CTLA4 Antibody

 
Mouse monoclonal (KT56) antibody to CTLA4 from Absea Biotechnology (030501A08).
Overview
Name: Anti-CTLA4 Antibody
Description: Mouse monoclonal (KT56) antibody to CTLA4.
Applications: sELISA, WB
Reactivity: Human
Immunogen: Recombinant human CTLA-4.
Host: Mouse
Clonality: Monoclonal
Clone: KT56
Isotype: IgG1
Conjugate: Unconjugated
Purification: IgG is purified through a Protein A column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target
Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Tissue Specificity: Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.
Involvement in Disease: Systemic lupus erythematosus: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.

Diabetes mellitus, insulin-dependent, 12: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

Celiac disease 3: A multifactorial, chronic disorder of the small intestine caused by intolerance to gluten. It is characterized by immune-mediated enteropathy associated with failed intestinal absorption, and malnutrition. In predisposed individuals, the ingestion of gluten-containing food such as wheat and rye induces a flat jejunal mucosa with infiltration of lymphocytes.

Autoimmune lymphoproliferative syndrome 5: An autosomal dominant primary immunodeficiency characterized by severe autoimmunity, infiltration of non-lymphoid organs, such as the intestine, lungs and brain, by hyperactive T cells and B cells, autoimmune cytopenias, and hypogammaglobulinemia in early childhood.
Post-Translational Modification: N-glycosylation is important for dimerization.
Cellular Location: Cell membrane.

Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.
UniProt: P16410
Gene ID: 1493
Synonyms: ALPS5 Antibody
CD Antibody
CD 152 Antibody
CD152 Antibody
CD152 antigen Antibody
CD152 isoform Antibody
Celiac disease 3 Antibody
CELIAC3 Antibody
CTLA 4 Antibody
CTLA-4 Antibody
CTLA4_HUMAN Antibody
Cytotoxic T cell associated 4 Antibody
Cytotoxic T lymphocyte antigen 4 Antibody
Cytotoxic T lymphocyte associated 4 Antibody
Cytotoxic T lymphocyte associated 4, soluble isoform, included Antibody
Cytotoxic T lymphocyte associated antigen 4 Antibody
Cytotoxic T lymphocyte associated antigen 4 short spliced form Antibody
Cytotoxic T lymphocyte associated protein 4 Antibody
Cytotoxic T lymphocyte associated serine esterase 4 Antibody
Cytotoxic T lymphocyte protein 4 Antibody
Cytotoxic T-lymphocyte protein 4 Antibody
Cytotoxic T-lymphocyte-associated antigen 4 Antibody
GRD4 Antibody
GSE Antibody
ICOS Antibody
IDDM12 Antibody
insulin-dependent diabetes mellitus 12 Antibody
Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4 Antibody
OTTHUMP00000216623 Antibody
Information: Target information shown above is from the UniProt Consortium.

Images
Sandwich ELISA - Anti-CTLA4 Antibody from Absea Biotechnology (030501A08) - Antibodies.com
Sandwich ELISA using KT56 coated plate and HRP conjugated KT50.


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Product Citations (2)
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Description: Rabbit polyclonal antibody to ICOS.
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Description: Rabbit polyclonal antibody to CTLA4
Application: ELISA, ICC, IF, IHC, IP, WB
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 150-200 on human CTLA4 protein.

£372

Description: Goat polyclonal antibody to ICOS.
Application: ELISA, IHC
Host: Goat
Isotype: IgG
Reactivity: Human

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Please Note: Anti-CTLA4 Antibody is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | 030501A08
Size Price Quantity
100µg £178
200µg £259
1mg £682

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Lead Time: Currently 4-6 Days
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