Anti-delta 1 Catenin Antibody [25a] (A248303)

Anti-delta 1 Catenin Antibody [25a]

Mouse monoclonal [25a] antibody to delta 1 Catenin.

The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas) was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. Its characteristic Arm domain that is composed of 42-amino acid motif repeats evidences this similarity. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.

ELISA, Flow Cytometry, IF

Flow Cytometry: 1-2 µg/million cells, IF: 1-2 µg/ml

Human, Mouse, Rat

Mouse delta 1 Catenin (phospho Tyr96).

Mouse

Monoclonal

25a

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

120 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

This monoclonal antibody is also available in a different formulation without BSA and Sodium Azide - Anti-delta 1 Catenin Antibody [25a] - BSA and Azide free (A251485).

Cadherin associated Src substrate, Cadherin-associated Src substrate, CAS, Catenin (cadherin associated protein) delta 1, Catenin delta, Catenin delta 1, Catenin delta-1, CTND1_HUMAN, CTNND, CTNND 1, CTNND1, KIAA0384, p120, P120 CAS, p120 catenin, P120 CTN, p120(cas), p120(ctn), P120CAS, P120CTN