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Anti-ETS1 associated protein II Antibody (FITC)

 
Rabbit polyclonal antibody to ETS1 associated protein II (FITC) from FabGennix (TDP2-FITC).
Overview
Name: Anti-ETS1 associated protein II Antibody (FITC)
Description: Rabbit polyclonal antibody to ETS1 associated protein II (FITC)
Applications: ELISA, WB
Dilutions: DB: 1:10,000; ELISA: 1:10,000; Western Blot: 1:1,000
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide taken within amino acid region 330-360 on human Tyrosyl-DNA phosphodiesterase protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: FITC
Concentration: 0.58 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage

Target
Function: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation.
Tissue Specificity: Widely expressed (PubMed:10764746). Highly expressed in various brain regions, including the frontal and occipital lobes, the hippocampus, the striatum and the cerebellum (PubMed:24658003).
Involvement in Disease: Spinocerebellar ataxia, autosomal recessive, 23: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR23 patients manifest epilepsy, intellectual disability, and gait ataxia.
Sequence Similarities: Belongs to the CCR4/nocturin family.
Post-Translational Modification: Ubiquitinated by TRAF6.
Cellular Location: Nucleus. Nucleus > PML body. Nucleus > Nucleolus. Cytoplasm.

Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein.
UniProt: O95551
Synonyms: 5'-Tyr-DNA phosphodiesterase Antibody
5'-tyrosyl-DNA phosphodiesterase Antibody
AD 022 Antibody
AD022 Antibody
dJ30M3.3 Antibody
EAP 2 Antibody
EAP II Antibody
EAP2 Antibody
EAPII Antibody
ETS 1 associated protein 2 Antibody
ETS 1 associated protein II Antibody
ETS1 associated protein 2 Antibody
ETS1-associated protein 2 Antibody
ETS1-associated protein II Antibody
MGC111021 Antibody
MGC9099 Antibody
RP1-30M3.3 Antibody
tdp2 Antibody
TRAF and TNF receptor associated protein Antibody
TRAF and TNF receptor-associated protein Antibody
TTRAP Antibody
TYDP2_HUMAN Antibody
Tyr DNA phosphodiesterase 2 Antibody
Tyr-DNA phosphodiesterase 2 Antibody
Tyrosyl DNA phosphodiesterase 2 Antibody
Tyrosyl-DNA phosphodiesterase 2 Antibody
Information: Target information shown above is from the UniProt Consortium.


Please Note: Anti-ETS1 associated protein II Antibody (FITC) is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | TDP2-FITC
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