+44 (0)1223 298875

Anti-Fibroblast Growth Factor 1 Antibody

 
Rat monoclonal (KT116) antibody to Fibroblast growth factor 1 from Absea Biotechnology (031113E03).
Overview
Name: Anti-Fibroblast Growth Factor 1 Antibody
Description: Rat monoclonal (KT116) antibody to Fibroblast growth factor 1.
Applications: ELISA, WB
Reactivity: Human
Immunogen: Recombinant human aFGF.
Host: Rat
Clonality: Monoclonal
Clone: KT116
Isotype: IgG2a
Conjugate: Unconjugated
Purification: IgG is purified through a Protein G column.
Concentration: 1 mg/ml in PBS containing 0.09% sodium azide as a preservative.
Storage: 4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.

Target
Function: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).
Tissue Specificity: Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
Sequence Similarities: Belongs to the heparin-binding growth factors family.
Post-Translational Modification: In the nucleus, phosphorylated by PKC/PRKCD.
Cellular Location: Secreted. Cytoplasm. Cytoplasm > Cell cortex. Cytoplasm > Cytosol. Nucleus.

Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
UniProt: P05230
Gene ID: 2246
Synonyms: Acidic fibroblast growth factor Antibody
aFGF Antibody
Beta endothelial cell growth factor Antibody
Beta-endothelial cell growth factor Antibody
ECGF Antibody
ECGF beta Antibody
ECGF-beta Antibody
ECGFA Antibody
ECGFB Antibody
Endothelial Cell Growth Factor alpha Antibody
Endothelial Cell Growth Factor beta Antibody
FGF 1 Antibody
FGF alpha Antibody
FGF1 Antibody
FGF1_HUMAN Antibody
FGFA Antibody
Fibroblast Growth Factor 1 Acidic Antibody
GLIO703 Antibody
HBGF 1 Antibody
HBGF-1 Antibody
HBGF1 Antibody
Heparin binding growth factor 1 Antibody
Heparin binding growth factor 1 precursor Antibody
Heparin-binding growth factor 1 Antibody
Information: Target information shown above is from the UniProt Consortium.

Images
Western Blot - Anti-Fibroblast Growth Factor 1 Antibody from Absea Biotechnology (031113E03) - Antibodies.com
Western blotting result.


Related Products
Description: Rabbit polyclonal antibody to FGF1.
Application: WB, IHC
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat

£148 – £372

Description: Rabbit polyclonal antibody to FGF1 (H56)
Application: WB, IHC
Host: Rabbit
Reactivity: Human, Mouse
Immunogen: Synthetic peptide, corresponding to amino acids 21-70 of Human FGF-1.

£165 – £283

Description: Rabbit polyclonal antibody to FGF1
Application: IHC
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide corresponding to a region derived from internal residues of human Fibroblast growth factor 1

£234

Description: Rabbit polyclonal antibody to Fibroblast growth factor 1
Application: WB
Host: Rabbit
Reactivity: Mouse
Immunogen: Recombinant mouse Fibroblast growth factor 1 protein

£301


Please Note: Anti-Fibroblast Growth Factor 1 Antibody is for research use only. It is not intended for diagnostic of therapeutic use.
Antibodies.com | 031113E03
Size Price Quantity
100µg £178
200µg £259
1mg £682

or
Request a quotation
Contact Us Directly
  • call icon + 44 (0)1223 298 875
  • + 44 (0)1223 281 447
  • email icon info@antibodies.com
Product Quality
  • guarantee icon
  • We promise guaranteed product quality
  • and expert customer service.
Lead Time: Currently 4-6 Days
Shipping Information
  • £20 to United Kingdom
  • £35 to Europe