Anti-Fibroblast Growth Factor 1 Antibody
Rat monoclonal (KT116) antibody to Fibroblast growth factor 1 from Absea Biotechnology (031113E03).
|Name:||Anti-Fibroblast Growth Factor 1 Antibody|
|Description:||Rat monoclonal (KT116) antibody to Fibroblast growth factor 1.|
|Immunogen:||Recombinant human aFGF.|
|Purification:||IgG is purified through a Protein G column.|
|Concentration:||1 mg/ml in PBS containing 0.09% sodium azide as a preservative.|
|Storage:||4 °C for 1 month, -20 °C or -80°C in aliquots. Avoid repeated freeze/thaw cycles.|
|Function:||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:18441324, PubMed:20422052). Can induce angiogenesis (PubMed:23469107).|
|Tissue Specificity:||Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.|
|Sequence Similarities:||Belongs to the heparin-binding growth factors family.|
|Post-Translational Modification:||In the nucleus, phosphorylated by PKC/PRKCD.|
|Cellular Location:||Secreted. Cytoplasm. Cytoplasm > Cell cortex. Cytoplasm > Cytosol. Nucleus.
Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
|Synonyms:||Acidic fibroblast growth factor Antibody
Beta endothelial cell growth factor Antibody
Beta-endothelial cell growth factor Antibody
ECGF beta Antibody
Endothelial Cell Growth Factor alpha Antibody
Endothelial Cell Growth Factor beta Antibody
FGF 1 Antibody
FGF alpha Antibody
Fibroblast Growth Factor 1 Acidic Antibody
HBGF 1 Antibody
Heparin binding growth factor 1 Antibody
Heparin binding growth factor 1 precursor Antibody
Heparin-binding growth factor 1 Antibody
|Information:||Target information shown above is from the UniProt Consortium.|
Western blotting result.
Please Note: Anti-Fibroblast Growth Factor 1 Antibody is for research use only. It is not intended for diagnostic of therapeutic use.