Anti-GCET2 Antibody [HGAL/2834] (A315001)

Anti-GCET2 Antibody [HGAL/2834]

Mouse monoclonal [HGAL/2834] antibody to GCET2.

Recognizes a protein of ???kDa, which is identified as HGAL. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. HGAL is specifically expressed in germinal center B-cells, but is absent in mantle and marginal zone B-cells and in the inter-follicular and para-cortical regions in normal tonsils and lymph nodes. Its high degree of specificity for germinal center B-cells makes anti-HGAL an ideal marker for the detection of germinal center-derived B-cell lymphomas. HGAL expression has been used to help elucidate nodal marginal zone lymphoma (NMZL) from cases of diffuse follicle center lymphoma. Additionally, HGAL expression was shown to correlate with survival in patients with diffuse large B-cell lymphoma (DLBCL).

Daudi, Raji or U266 cells. Human lymphocytes. Human lymph node, tonsil or testis.

IHC: 1-2 µg/ml

Human

Recombinant fragment (around Amino Acids 1-200) of human HGAL protein. The exact sequence is proprietary.

Mouse

Monoclonal

HGAL/2834

IgG1

Unconjugated

Protein A/G chromatography.

200 µg/ml

21 kDa

Liquid

Supplied in 10mM Phosphate Buffered Saline with 0.05% BSA and 0.05% Sodium Azide.

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

GCAT2, Gcet, GCET2 germinal center expressed transcript 2, GCET2 germinal centre expressed transcript 2, Gcsam, GCSAM_HUMAN, Germinal center associated lymphoma, Germinal center associated lymphoma protein, Germinal center B cell associated protein 2, Germinal center B-cell-expressed transcript 2 protein, Germinal center expressed transcript 2, Germinal center-associated lymphoma protein, Germinal center-associated signaling and motility protein, Germinal centre associated lymphoma, Germinal centre associated lymphoma protein, Germinal centre B cell associated protein 2, Germinal centre expressed transcript 2, hGAL, M17, M17 L