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Anti-Glutamate Receptor 2 Antibody

Rabbit polyclonal antibody to Glutamate Receptor 2 from FabGennix (GLUR2-201AP).
Name: Anti-Glutamate Receptor 2 Antibody
Description: Rabbit polyclonal antibody to Glutamate Receptor 2
Applications: CM, ELISA, ICC, IF, IHC, WB
Dilutions: Confocal Microscopy: 1:50; DB: 1:10,000; ELISA: 1:10,000; Immunocytochemistry: 1:50; Immunofluorescence: 1:50; Immunohistochemistry: 1:50; Western Blot: 1:500
Reactivity: Human, Monkey
Immunogen: Synthetic peptide corresponding to unique amino acid region on GluR2 protein.
Host: Rabbit
Clonality: Polyclonal
Conjugate: Unconjugated
Concentration: 0.64-0.72 µg/µl in antibody stabilization buffer
Storage: -20⁰C for long term storage
Function: Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Sequence Similarities: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA2 subfamily.
Post-Translational Modification: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-610 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-836 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
Cellular Location: Cell membrane. Endoplasmic reticulum membrane. Cell junction > Synapse > Postsynaptic cell membrane.

Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.
UniProt: P42262
Please Note: All batches are extensively validated and are guaranteed to work as specified, however, QC data is not necessarily from the current lot on sale.


Description: Rabbit Polyclonal Antibody to Glutamate receptor 2
Application: ELISA, WB, IP
Host: Rabbit
Isotype: IgG
Immunogen: glutamate receptor, ionotropic, AMPA 2


Please Note: Anti-Glutamate Receptor 2 Antibody is for research use only. It is not intended for diagnostic or therapeutic use.
Antibodies.com | GLUR2-201AP
Size Price Quantity
100µg £372

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