This antibody recognises CD49 antigen-like family member E, also known as integrin alpha-5 (ITGA5), integrin alpha-F and VLA-5. It belongs to the family of cell surface receptors and mediates signal transduction. CD49e was shown to regulate proliferation and adipogenic differentiation of human adipose derived stem cells. MicroRNA-205 (miR-205) down-regulates CD49e and this impairs triple negative breast cancer cell metastatic traits by inhibiting the Src/Vav2/Rac1 pathway.
Applications
WB
Dilutions
WB: 1:500 - 1:2,000
Reactivity
Human, Rat, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 750-1000 of human CD49e.
Approximately 135 kDa in various cell and tissue lysates under reducing conditions
Product Form
Liquid
Formulation
Supplied in Phosphate Buffered Saline with 50% Glycerol and 0.02% Sodium Azide.
Storage
Store undiluted at -20°C. Storage in frost free freezers is not recommended. Avoid freeze-thaw cycles. Should this product contain a precipitate we recommend microcentrifugation before use.
General Notes
Rabbit anti CD49e antibody recognizes CD49 antigen-like family member E, also known as integrin alpha-5 (ITGA5), integrin alpha-F and VLA-5. It belongs to the family of cell surface receptors and mediates signal transduction (Liu et al. 2000). CD49e was shown to regulate proliferation and adipogenic differentiation of human adipose derived stem cells (Morandi et al. 2016). MicroRNA-205 (miR-205) down-regulates CD49e and this impairs triple negative breast cancer cell metastatic traits by inhibiting the Src/Vav2/Rac1 pathway (Xiao et al. 2018).
Synonyms
CD49 antigen-like family member E, CD49e, Fibronectin receptor subunit alpha, FNRA, Integrin alpha-5, Integrin alpha-F, ITGA5, VLA-5
Chimeric monoclonal antibody to Integrin alpha 5 Research grade Volociximab biosimilar for ELISA, Flow Cytometry, Functional Studies and in vivo Research.
Chimeric monoclonal antibody to Integrin alpha 5 Research grade Volociximab biosimilar for ELISA, Flow Cytometry, Functional Studies and in vivo Research.
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