Anti-Interferon alpha Antibody [UMCh3-IFNa] (A281892)

Anti-Interferon alpha Antibody [UMCh3-IFNa]

Mouse monoclonal [UMCh3-IFNa] antibody to Interferon alpha.

This antibody recognises chicken Interferon alpha (chIFN-alpha).The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken.There are similarities between chicken IFN and mammalian IFNI with conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Chicken IFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that chicken IFN acts as a potent antiviral agent. Mouse anti Chicken interferon alpha antibody, clone UMCh3-IFNa does not cross react with IFN beta or IFN gamma and does not neutralize chIFN-alpha.

WB, ELISA

Chicken

Recombinant Chicken Interferon alpha.

Mouse

Monoclonal

UMCh3-IFNa

IgG1

Unconjugated

Protein G affinity chromatography of ascites.

Approximately 19 kDa.

Liquid

Supplied in Phosphate Buffered Saline with <0.1% Sodium Azide.

Shipped at ambient temperature. Upon delivery aliquot and store at -20°C. When thawed, aliquot the sample as needed. Short term (up to 4 weeks): store at 4°C. Long term: store at -20°C. Avoid freeze / thaw cycles. Storage in frost free freezers is not recommended.

Mouse anti Chicken interferon alpha antibody, clone UMCh3-IFNa recognizes chicken Interferon alpha (chIFN-alpha).The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken.There are similarities between chicken IFN and mammalian IFNI with conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes (Staeheli et al. 2001). Chicken IFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that chicken IFN acts as a potent antiviral agent (Marcus et al. 1999). Mouse anti Chicken interferon alpha antibody, clone UMCh3-IFNa does not cross react with IFN beta or IFN gamma and does not neutralize chIFN-alpha.

IFL, IFN, IFN alpha, IFN alpha 1/13, IFN alpha 1b, IFN alphaD, IFN-alpha-1/13, IFNA1, IFNA13, IFNA1_HUMAN, IFNA@, Interferon alpha 1, Interferon alpha-1/13, Interferon alpha-D, Interferon alpha1, Interferon, alpha 13, LeIF D